Yancen Liu

• Compared with traditional synthetic chemistry, supramolecular chemistry focus on systems organized by noncovalent interactions. Host-guest chemistry is a vigorous field of supramolecular chemistry. However, researchers have paid lots of attention mainly in thermodynamics of host-guest binding, while their kinetics did not receive enough concern. Actually, kinetics investigation provides more information than thermodynamics, especially related to mechanism. In this thesis, we try to inspect the host-guest binding from the perspective of kinetics. For example, fast-exchanged host-dye reporter pairs are used for monitoring slower process. Slow-exchanged rotaxanes are stable enough to be used as functional materials. In Chapter 1, we briefly introduced the host-guest chemistry and supramolecular kinetics. In Chapter 2, we used two reporter pairs to monitor reaction of kinase and phosphatase, as well as screening inhibitor. In Chapter 3, a supramolecular relay process of CBs and a putrescine derivative of aminomethyladamantane has been monitored by reporter pairs, in a ratiometric manner. In Chapter 4, a series of kinetically stable polyrotaxanes constructed by CDs and conjugated polymers have been synthesized and characterized, they are potential materials for optoelectronic applications. In Chapter 5, amphiphilic calixarenes were investigated as counterion activators for peptide transport, both through synthetic lipid membrane and cell membrane, by lowering the kinetic barrier.